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  1. A comprehensive review of opioid-induced hyperalgesia

    Opioid-induced hyperalgesia (OIH) is defined as a state of nociceptive sensitization caused by exposure to opioids. The condition is characterized by a paradoxical response whereby a …

  2. The keywords used were opioid-induced hyperalgesia, allodynia, opioid with-drawal, addiction, opioid or opiate tolerance, neuropathic pain, chemically induced pain, and hyperpathia.

  3. More opioids, more pain: Fueling the fire - Harvard Health

    Jul 8, 2019 · The mechanism behind opioid-induced hyperalgesia is complex and involves molecular and chemical changes in the brain and spinal cord. Opioids tend to activate specific …

  4. Opioid-induced hyperalgesia - Wikipedia

    Opioid-induced hyperalgesia (OIH) or opioid-induced abnormal pain sensitivity, also called paradoxical hyperalgesia, is an uncommon condition of generalized pain caused by the long …

  5. National Center for Biotechnology Information

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  6. Opioid-Induced Hyperalgesia: Causes, Symptoms, Treatment

    Dec 9, 2024 · Opioid-induced hyperalgesia is a condition in which opioids intensify pain instead of alleviating it. It tends to occur with prolonged opioid use.

  7. Opioid-Induced Hyperalgesia (OIH): This is when your pain actually increases or you become more sensitive to pain, despite taking opioids. The pain might feel different from your original …

  8. Opioid-Induced Hyperalgesia

    Aug 24, 2017 · Hyperalgesia is an enhanced pain response. It can result from either injury to part of the body or from use of opioid painkillers. When a person becomes more sensitive to pain …