p53, also known as tumor protein p53, TP53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is often …

This is a heavily studied pathway in cancer biology and oncology with a history that dates back to 1979 when p53 was discovered. The p53 pathway is a complex cellular stress response network with …

Mar 1, 2023 · Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression. We also discuss key …

The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing …

Jun 15, 2025 · At the heart of this defense is a protein known as p53, often called the “guardian of the genome.” This protein is a component of a pathway that responds to cellular stress, working to keep …

Jan 1, 2025 · We propose a model for how DNA binding by p53 is regulated by its disordered regions. Defects in the tumor suppressor protein p53 are found in the majority of cancers.

The perturbation of p53 signaling pathways is required for the development of most cancers; however, it is now becoming clear that p53 has a much broader role in human health and diseases.

Apr 29, 2025 · Explore the p53 signaling pathway, its regulatory mechanisms, and its role in maintaining cellular integrity and response to stress.

2 days ago · The protein p53, best known as the "guardian of the genome" for its role in preventing cancer, can affect blood vessels in different ways. However, it has not been clear how p53 can slow …

Apr 9, 2025 · This Review discusses the roles, mechanisms and physiological settings in which NACDs are regulated by p53, and their potential targeting for the treatment of human diseases.